Pharmacogenetic Aspects of Postoperative Anesthesia with Ketoprofen in Cardiac Surgery Patients

Aim. Evaluation of the effect polymorphisms CYP2D6, CYP2C8 genes on efficacy and safety postoperative analgesia with ketoprofen in patients coronary artery disease after cardiac surgery. Material methods . The study included 90 an established diagnosis period Patients received 100 mg intramuscularly 2 times a day for 5 days. intensity pain was rated by Numeric Rating Scale. severity dyspepsia assessed Gastrointestinal Symptom Scale (GSRS) questionnaire. DNA isolated from venous blood using automated system. Single nucleotide (C>T) rs11572080, CYP2D6*4 (1846G>A) rs3892097 were determined real-time polymerase chain reaction method. Results. In genotypes GA GG allelic variant CYP2D6*4, significant differences syndrome found days 4 period: 3,91±2,17 4,95±1,8 points (p=0,04), 3,52±1,95 4,5±1,7 (p=0,04) 5, respectively. CT genotype GSRS significantly higher than CC genotype: 22,67±7,64 18,97±4,25 points, Conclusion. showed lower genotype. revealed